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Externally controlled drug release from nanoscale drug delivery systems hold great potential to increase local deposit. Here, we introduce an ultrasound-activatable porphyrin-phospholipid liposome (PPL) to show its controllable drug release, enhanced imaging signals, and efficient therapeutic actions.
The therapeutic effect of chemotherapy of glioblastoma is very limited due to the existence of blood-brain barrier. Focused ultrasound combined with microbubbles is an attractive method to deliver therapeutic agents to brain tissue noninvasively, transiently and locally. Paclitaxel is a potent anti-cancer agent. Thus, the objective of this study is to investigate the therapeutic effect of paclitaxel...
The aim of our study was to investigate the use of targeted ultrasound microbubbles (MBs) for molecular imaging of murine endothelial CD81 expression. In the study, the anti-CD81-coated MBs was successfully prepared and characterizated. Murine bEnd.3 cells were stimulated with phenazine methosulfate (PMS) to induce the up-regulation of CD81 expression. Changes in CD81 expression after stimulation...
Microbubbles (MBs) coated by surfactant or polymer have been shown to be the most effective contrast agents for diagnostic ultrasound contrast imaging and targeted molecular imaging. With the development of both diagnostic and therapeutic applications of ultrasound contrast agents (UCAs), there is a demand for new preparation technologies to provide a high degree of control over MB size, composition,...
We have developed a novel lipid ultrasonic microbubble (MB) carrying paclitaxel (PTX) and LyP-1 peptides and investigated its tumor-targeted efficiency and chemotherapy effect in vitro. Results showed the attachment of targeted drug-loaded MBs to human MDA-MB-231 breast cancer cells was highly efficient and stable under both static and dynamic conditions. Also, the targeted drug-loaded MBs showed...
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