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AimTo examine whether sympathetic afferent stimulation (SAS) inhibits central vagal activation induced by α2‐adrenergic stimulation.
MethodsIn anaesthetized Wistar‐Kyoto rats, a cardiac microdialysis technique was applied to the left ventricle, and the effect of α2‐adrenergic stimulation by medetomidine on myocardial interstitial acetylcholine (ACh) levels was examined in the absence (n = 6) or the...
AimTo elucidate the abnormality of vagal control in spontaneously hypertensive rats (SHR) by measuring left ventricular myocardial interstitial acetylcholine (ACh) release in response to α2‐adrenergic stimulation as an index of in vivo vagal nerve activity.
MethodsA cardiac microdialysis technique was applied to the rat left ventricle in vivo, and the effect of α2‐adrenergic stimulation by medetomidine...
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