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Background
Surfactant protein D (SPD) is a member of the collectin family that lines the airway epithelial cells with host defense. However, the role of SPD in the pathogenesis of aspirin‐exacerbated respiratory disease (AERD) is still unclear.
Methods
The serum SPD level was measured in patients with AERD (n = 336), those with aspirin‐tolerant asthma (ATA, n = 442), and healthy controls (HC, n = 104)...
Background
To date, there has been no reliable in vitro test to diagnose aspirin‐exacerbated respiratory disease (AERD).
Objective
To investigate potential diagnostic biomarkers for AERD using metabolomic analysis.
Methods
An untargeted profile of serum from asthmatics in the first cohort (group 1) comprising 45 AERD, 44 patients with aspirin‐tolerant asthma (ATA), and 28 normal controls was...
BackgroundEosinophil activation is the key feature of upper and lower airway inflammation in aspirin‐exacerbated respiratory disease (AERD).
ObjectiveTo investigate the mechanism of eosinophil activation and identify novel inflammatory mediators using proteomics.
MethodsThirty‐two asthmatic subjects were enrolled: 18 AERD patients who showed positive responses to the lysine‐aspirin nasal provocation...
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