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AimsThere is general acceptance that the physiological relationship between insulin sensitivity and insulin secretion is hyperbolic. This conclusion has evolved from studies in which one test assessed both variables, and changes in plasma insulin concentration were used as a surrogate measure for insulin secretion rate. The aim of this study was to see if a hyperbolic relationship would also emerge...
Diabet. Med. 28, 1487–1493 (2011)
AbstractSir Harold Himsworth was a renowned clinician and researcher. Among his myriad of accomplishments, he was the first to differentiate diabetes mellitus into ‘insulin‐sensitive’ and ‘insulin‐insensitive’ forms. To help distinguish these two types, he developed the first test to measure insulin sensitivity, the insulin–glucose test. This article reviews Himsworth’s...
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