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Atomic force microscopy (AFM) is originally used to observe the sample surface, and then extended to the area of nano-manipulation. It can be quite valuable in the further study of maneuvering nano-particles. Because of the influence of the tip morphology on the tip pushing direction, it is difficult to establish an effective operating model for stably manipulating nanoparticles with controllable...
Graphene has been widely studied because of its high mobility, superior mechanical properties and excellent thermal and chemical stability. This paper describes a novel and flexible method to fabricate graphene interdigitated electrodes and all-carbon field effect transistor (FET). In this approach, graphene is first grown by chemical vapor deposition (CVD) and assembled onto a microelectrode chip...
Atomic force microscopy (AFM) and dielectrophoresis (DEP) technologies have been used as excellent tools for nanomanipulation and nanoassembly. AFM-based manipulation exhibits excellent positioning and very high accuracy. The advantage of DEP is its ability to carry out parallel and massive manipulation of nanomaterials. In this study, we develop AFM tip-induced dielectrophoresis for three dimensional...
One of the prerequisites for AFM based nanomanipulation is that the position of the target nanoparticle can be stable controlled within a known area, while this prerequisite is still hindered by the uncertainties including the initial position of the nanoparticle and of the AFM tip, together with the uncertain forces from the substrate and so on. In this paper, a Stochastic Pushing (SP) model and...
The treatment of Non-Hodgkin's lymphoma (NHL) was revolutionized by the approval of rituximab in 1997. Rituximab is a CD20-directed monoclonal antibody (mAb). Despite the great success of rituximab in the treatment of B-cell NHL, the urgent need is to enhance the efficacy due to the markedly variable patient responses. Hence elucidating the molecular mechanisms of rituximab's anti-cancer effect is...
Illuminating the underlying mechanism of drug action at single-cell and single-molecule levels is of great significance for the personalized treatment of diseases. In this paper, with the use of the atomic force microscopy (AFM), the mechanical property of the lymphoma cells was quantitatively measured and the CD20-Rituximab binding force was measured on the surface of the lymphoma cells by linking...
Rapid progress in graphene-based applications is calling for an inexpensive technique for creating mass graphene components with specialized shapes, sizes, and edge structures. In this paper, an Atomic Force Microscopy (AFM) based mechanical cutting method is developed to approach this goal, through which we are able to structure trenches into multilayer graphene flakes with different directions,...
In developing nano-devices and nano-structures, traditional methodologies on MEMS meet the difficulty from the scale restriction. With the strategy of objects assembly, using AFM to handle nano-rods and other nano-objects is considered as an important and high potential technology in constructing nano-structures. However most of AFM only has one tip as the end effector and cannot control both translational...
Cell stiffness is closely related to human health and diseases. Measuring the mechanical property of individual cells may help us to understand the mechanism of diseases at cell level and provide new methods for disease diagnosis and personalized treatment. In this paper, the poly-l-lysine was used to immobilize Burkitt's lymphoma (BL)cells onto the glass substrate for being imaged in fluid by atomic...
Burkitt's lymphoma (BL) is a highly aggressive malignant tumor with high morbidity rate in children. Patients have different responses to the same therapy due to the molecular heterogeneity. Detailed observation of the surface structure of BL cells to locate the specific receptors (CD20) on the cell surface and measure the binding force between the CD20s and their cognate ligands (Rituximab) may give...
After much initial controversy over the past 20 years, the mechanism of charge-transfer in DNA is now moving towards a consensus view in the chemistry community that the dominant charge-transfer mechanism appears to be distance-dependent coherent tunnelling through unit-step and weak-distance-dependent thermal hopping through multi-step. Contrary to the consensus in the chemistry society, the problem...
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