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Hypoxia presents pro-apoptotic and anti-apoptotic biphasic effects that appear to be dependent upon cell types and conditions around cells. The substantial reports demonstrated that commonly used hypoxia-mimetic agents cobalt chloride (CoCl2) and desferrioxamine (DFO) could also induce apoptosis in many different kinds of cells, but the mechanism was poorly understood. In this work, we compare the...
Apoptosis can be triggered by different forms of cellular stress. We here show that serum deprivation induces the expression and secretion of type I interferons and results in apoptosis in RAW 264.7 cell in a caspase dependent manner. Administration of either IFN-α or IFN-β antibody partially inhibits apoptosis while the two antibodies used together totally prevents RAW264.7 cell from apoptosis. GM-CSF,...
Our recent data implicated small molecular weight G-proteins (e.g., H-Ras) in interleukin 1β (IL 1β)-induced metabolic dysfunction and apoptotic demise of the islet β cell (Tannous et al., Biochem Pharmacol 2001; 62:1459–1468, Kowluru and Morgan, Biochem Pharmacol, 2002; 63:1027–1035, Chen et al. Biochem Pharmacol, 2003; 66:1681–1694). Recently, we have shown that mastoparan, a tetradecapeptide from...
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