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1. The renal vasodilatory effect of YM435 was used as an index of its dopamine DA 1 receptor agonist activity and compared with that of dopamine in pentobarbital-anesthetized dogs.2. Intrarenal arterial administration of YM435 (0.1 to 10 μg) and dopamine (1 to 100 μg) produced a dose-dependent increase in renal blood flow. The doses of YM435 and dopamine required to cause a 30-ml/min increase...
Fluorine-18 labeled analog of d-fructose, 1-deoxy-1-[ 18 F]fluoro-d-fructose (1-[ 18 F]FDFrc), was synthesized by nucleophilic substitution of [ 18 F]fluoride ion and the effect of the fluorine substitution on its in vivo metabolism was investigated. The tissue distributions of 1-[ 18 F]FDFrc in rats and tumor bearing mice showed initial high uptake...
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