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Cardiac effects of catecholamines on the L-type calcium channel depend on -adrenoceptor subtype (1- vs. 2-adrenoceptor). Chronic overexpression of these receptors leads to hypertrophy and early death at moderate (1) or excessive (2) levels of overexpression respectively. In order to examine the role of L-type calcium channels in altered cardiomyocyte calcium homeostasis found with 1-adrenoceptor overexpression,...
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