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Nitric oxide (NO) markedly induces cardiomyocyte (CM) differentiation of embryonic stem (ES) cells. Here we examined the role of the Ca2+ signaling in the NO-induced CM differentiation of mouse ES cells. We found that NO induced intracellular Ca2+ increases in ES cells in a dose-dependent manner, and application of IP3 pathway antagonists not only significantly inhibited this induced Ca2+ increase...
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