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Identifying essential proteins is important for understanding the minimal requirements for cellular survival and development. Fast growth in the amount of available protein-protein interactions has produced unprecedented opportunities for detecting protein essentiality on network level. A series of centrality measures have been proposed to discover essential proteins based on network topology. However,...
Essential proteins are indispensable to support cellular life and constitute a minimal set required for a living cell. Fast progress in high-throughput technologies and large amount of data enable to discover essential proteins in system level by analyzing protein-protein interaction networks. A number of centrality algorithms are suggested to detect essential proteins, but they focus only on network...
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