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This paper focuses on the comparison of red blood cell (RBC) deformability under continuous and repetitive loadings. We utilized a feedback position-control system and a narrow microfluidic channel for applying different deformation patterns on RBCs. According to the analyses of shape recoveries with different patterns, we found, for the first time, that the mechanical responses of RBCs upon continuous...
A high-resolution cell manipulation system is presented for investigating red blood cell deformation under long-standing load in this paper. Because the low Reynolds number in microfluidic system, cell position can be manipulated by controlling the flow in a microchannel. A high-speed vision system is embedded in the system for providing cell present position as the feedback signal for the controller...
During the deformability test of Red Blood Cell (RBC) by utilizing a micro fluidic channel, we found an interesting phenomenon where some RBCs behave just like elastic pinball with the motion in the perpendicular direction with respect to the main flow line, while most of RBCs simply move along the main flow line. This phenomenon is called “Cell Pinball”. Through visualization, we found that the RBC...
This paper reports the on-chip Fluid Separated Volumetric Flow Converter (FSVFC) capable of high speed cell position control with high resolution. There are various situations where we need to avoid mixing working fluid and actuation fluid for biological considerations, and such demand motivates the development of FSVFC. The proposed on-chip comb shaped FSVFC is composed of two separated groups of...
A method for evaluating red blood cell (RBC) deformability by different channel width in a microfluidic device is proposed. While conventional methods usually have only one test channel to deform RBCs for the evaluation, a design including three test channels with different width is utilized in this work. The proposed design have the advantage of generating a wider range of deformation to each RBC,...
This paper discusses the observability of cell stiffness by utilizing a micro-channel whose diameter is slightly smaller than that of a cell. By modeling each cell with distributed springs and dampers, we discuss how many sensing points are necessary and sufficient for evaluating cell stiffness. We define the observability by the velocity of each cell through a micro-channel based upon the experimental...
This paper proposes a high speed cell stiffness evaluation with high reliability. The procedure includes both online measurement and offline inspection. By using the property where the passing time of the cell in the micro channel is a function of the cell stiffness and its size, a real time vision system whose handling frequency is 6 kHz can capture the size as well as the passing time of each cell...
Stiffness is an important index to know the quality of a cell. While there have been a couple of works to evaluate the cell stiffness in real time by combining a micro fluid chip with electric impedance based cell counters, we can not see what is really happening in the channel after all. The challenge of this paper is to develop a system capable of evaluating the cell stiffness in real time and of...
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