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A process that combines polymer nanoreplica molding with horizontal dipping was used to fabricate large area ( ) distributed feedback laser biosensors (DFBLB) on flexible plastic substrates, which were subsequently incorporated into standard format 96-well microplates. A room temperature nanoreplica molding process was used to create subwavelength periodic grating structures,...
We characterized the uniformity and sensitivity of the distributed feedback laser biosensors in 96-well microplate format, with a thickness standard deviation of ∼35 nm. An assay was also used to demonstrate its biomolecule detection ability.
We present a model for predicting photonic crystal label-free biosensor performance based primarily on the spatial distribution of electromagnetic near fields at device resonance. To achieve maximum device sensitivity, the resonant fields can be shaped by careful choice of material and geometrical parameters. The effect of each property on the resonant mode profile, and consequently on sensor performance,...
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