Search results for: Grace Parraga

Items from 1 to 20 out of 67 results

article

Review of Hyperpolarized Pulmonary Functional ¹²⁹Xe MR for Long‐COVID

Jim M. Wild, Fergus V. Gleeson, Sarah Svenningsen, James T. Grist, more

Journal of Magnetic Resonance Imaging > 59 > 4 > spcone - spcone

Pathologies potentially involved in long‐covid. Pulmonary airways and vessels (including micro‐vascular perfusion), as well as terminal airways/alveolar, cardiac abnormalities may play a role in the expression of respiratory symptoms in long‐covid. ARDS = Acute respiratory distress syndrome; COPD = Chronic obstructive pulmonary disease. By Wild et al. (1120‐1134)

article

Review of Hyperpolarized Pulmonary Functional ¹²⁹Xe MR for Long‐COVID

Jim M. Wild, Fergus V. Gleeson, Sarah Svenningsen, James T. Grist, more

Journal of Magnetic Resonance Imaging > 59 > 4 > 1120 - 1134

The respiratory consequences of acute COVID‐19 infection and related symptoms tend to resolve 4 weeks post‐infection. However, for some patients, new, recurrent, or persisting symptoms remain beyond the acute phase and persist for months, post‐infection. The symptoms that remain have been referred to as long‐COVID. A number of research sites employed ¹²⁹Xe magnetic resonance imaging (MRI) during...

article

Physical activity levels, pulmonary function, and MRI in children born extremely preterm: A comparison between children with and without bronchopulmonary dysplasia

Rhiana Roeper, Henrietta Blinder, Lamia Hayawi, Nicholas Barrowman, more

Pediatric Pulmonology > 58 > 5 > 1492 - 1500

Introduction Children with a history of bronchopulmonary dysplasia (BPD) may have lower physical activity levels, but evidence to date is mixed. This study compared physical activity levels between children born extremely preterm with and without history of BPD, and examined their associations with pulmonary magnetic resonance imaging (MRI) and pulmonary function test (PFT) indices. Methods This...

article

Pulmonary MRI and Cluster Analysis Help Identify Novel Asthma Phenotypes

Rachel L. Eddy, Marrissa J. McIntosh, Alexander M. Matheson, David G. McCormack, more

Journal of Magnetic Resonance Imaging > 56 > 5 > 1475 - 1486

Background Outside eosinophilia, current clinical asthma phenotypes do not show strong relationships with disease pathogenesis or treatment responses. While chest x‐ray computed tomography (CT) phenotypes have previously been explored, functional MRI measurements provide complementary phenotypic information. Purpose To derive novel data‐driven asthma phenotypic clusters using functional MRI airway...

article

Pulmonary functional MRI: Detecting the structure–function pathologies that drive asthma symptoms and quality of life

Harkiran K. Kooner, Marrissa J. McIntosh, Vedanth Desaigoudar, Jonathan H. Rayment, more

Respirology > 27 > 2 > 114 - 133

Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation‐free gases (such as ³He and ¹²⁹Xe) provides a way to directly visualize inhaled gas distribution and ventilation defects (or ventilation heterogeneity) in real time with high spatial (~mm³) resolution. Both gases enable quantitative measurement of terminal airway morphology, while ¹²⁹Xe uniquely enables imaging the transfer of...

article

Protocols for multi‐site trials using hyperpolarized ¹²⁹Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the ¹²⁹Xe MRI clinical trials consortium

Peter J. Niedbalski, Chase S. Hall, Mario Castro, Rachel L. Eddy, more

Magnetic Resonance in Medicine > 86 > 6 > 2966 - 2986

Hyperpolarized (HP) ¹²⁹Xe MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly and safely, providing novel information not possible using conventional imaging modalities or pulmonary function tests. As such, there is mounting interest in expanding the use of biomarkers derived from HP ¹²⁹Xe MRI as outcome measures in multi‐site clinical trials across a range...

article

Accelerated ¹²⁹Xe MRI morphometry of terminal airspace enlargement: Feasibility in volunteers and those with alpha‐1 antitrypsin deficiency

Alexei Ouriadov, Fumin Guo, David G. McCormack, Grace Parraga

Magnetic Resonance in Medicine > 84 > 1 > 416 - 426

Purpose Multi‐b diffusion‐weighted hyperpolarized inhaled‐gas MRI provides imaging biomarkers of terminal airspace enlargement including ADC and mean linear intercept (L_m), but clinical translation has been limited because image acquisition requires relatively long or multiple breath‐holds that are not well‐tolerated by patients. Therefore, we aimed to accelerate single breath‐hold 3D multi‐b diffusion‐weighted...

article

Rapid single‐breath hyperpolarized noble gas MRI‐based biomarkers of airspace enlargement

Andrew Westcott, Fumin Guo, Grace Parraga, Alexei Ouriadov

Journal of Magnetic Resonance Imaging > 49 > 6 > 1713 - 1722

Background Multi‐b diffusion‐weighted hyperpolarized‐gas MRI measures pulmonary airspace‐enlargement using apparent diffusion coefficients (ADCs) and mean‐linear‐intercepts (L_m). Purpose To develop single‐breath 3D multi‐b diffusion‐weighted ³He and ¹²⁹Xe MRI using k‐space undersampling. Rapid, cost‐efficient, single‐breath acquisitions may facilitate clinical translation. Study Type Prospective...

article

Rapid single‐breath hyperpolarized noble gas MRI‐based biomarkers of airspace enlargement

Andrew Westcott, Fumin Guo, Grace Parraga, Alexei Ouriadov

Journal of Magnetic Resonance Imaging > 49 > 6 > spcone - spcone

article

A framework for Fourier‐decomposition free‐breathing pulmonary ¹H MRI ventilation measurements

Fumin Guo, Dante P.I. Capaldi, David G. McCormack, Aaron Fenster, more

Magnetic Resonance in Medicine > 81 > 3 > 2135 - 2146

Purpose To develop a rapid Fourier decomposition (FD) free‐breathing pulmonary ¹H MRI (FDMRI) image processing and biomarker pipeline for research use. Methods We acquired MRI in 20 asthmatic subjects using a balanced steady‐state free precession (bSSFP) sequence optimized for ventilation imaging. 2D ¹H MRI series were segmented by enforcing the spatial similarity between adjacent images and the...

article

Hyperpolarized ³He MRI ventilatory apparent diffusion coefficient of alpha‐1 antitrypsin deficiency

Andrew Westcott, Dante P.I. Capaldi, Alexei Ouriadov, David G. McCormack, more

Journal of Magnetic Resonance Imaging > 49 > 1 > 311 - 313

article

On the Potential Role of MRI Biomarkers of COPD to Guide Bronchoscopic Lung Volume Reduction

Colin J. Adams, Dante P.I. Capaldi, Robert Di Cesare, David G. McCormack, more

Academic Radiology > 2018 > 25 > 2 > 159-168

In patients with severe emphysema and poor quality of life, bronchoscopic lung volume reduction (BLVR) may be considered and guided based on lobar emphysema severity. In particular, x-ray computed tomography (CT) emphysema measurements are used to identify the most diseased and the second–most diseased lobes as BLVR targets. Inhaled gas magnetic resonance imaging (MRI) also provides chronic obstructive...

article

Pulmonary MRI morphometry modeling of airspace enlargement in chronic obstructive pulmonary disease and alpha‐1 antitrypsin deficiency

Alexei Ouriadov, Eric Lessard, Khadija Sheikh, Grace Parraga, more

Magnetic Resonance in Medicine > 79 > 1 > 439 - 448

Purpose We generated lung morphometry measurements using single‐breath diffusion‐weighted MRI and three different acinar duct models in healthy participants and patients with emphysema stemming from chronic obstructive lung disease (COPD) and alpha‐1 antitrypsin deficiency (AATD). Methods Single‐breath‐inhaled ³He MRI with five diffusion sensitizations (b‐value = 0, 1.6, 3.2, 4.8, and 6.4 s/cm²...

article

Pulmonary 3He Magnetic Resonance Imaging Biomarkers of Regional Airspace Enlargement in Alpha-1 Antitrypsin Deficiency

Eric Lessard, Heather M. Young, Anurag Bhalla, Damien Pike, more

Academic Radiology > 2017 > 24 > 11 > 1402-1411

Thoracic x-ray computed tomography (CT) and hyperpolarized ³He magnetic resonance imaging (MRI) provide quantitative measurements of airspace enlargement in patients with emphysema. For patients with panlobular emphysema due to alpha-1 antitrypsin deficiency (AATD), sensitive biomarkers of disease progression and response to therapy have been difficult to develop and exploit, especially those biomarkers...

article

Free-breathing Functional Pulmonary MRI

Dante P.I. Capaldi, Khadija Sheikh, Rachel L. Eddy, Fumin Guo, more

Academic Radiology > 2017 > 24 > 10 > 1268-1276

Ventilation heterogeneity is a hallmark feature of asthma. Our objective was to evaluate ventilation heterogeneity in patients with severe asthma, both pre- and post-salbutamol, as well as post-methacholine (MCh) challenge using the lung clearance index, free-breathing pulmonary ¹H magnetic resonance imaging (FDMRI), and inhaled-gas MRI ventilation defect percent (VDP).Sixteen severe asthmatics (49...

article

Ultrashort echo time MRI biomarkers of asthma

Khadija Sheikh, Fumin Guo, Dante P.I. Capaldi, Alexei Ouriadov, more

Journal of Magnetic Resonance Imaging > 45 > 4 > 1204 - 1215

Purpose To develop and assess ultrashort echo‐time (UTE) magnetic resonance imaging (MRI) biomarkers of lung function in asthma patients. Materials and Methods Thirty participants including 13 healthy volunteers and 17 asthmatics provided written informed consent to UTE and pulmonary function tests in addition to hyperpolarized‐noble‐gas 3T MRI and computed tomography (CT) for asthmatics only....

article

Why Is Your Patient Still Short of Breath? Understanding the Complex Pathophysiology of Dyspnea in Chronic Kidney Disease

Fabio Rosario Salerno, Grace Parraga, Christopher William McIntyre

Seminars in Dialysis > 30 > 1 > 50 - 57

Dyspnea is one of the most common symptoms associated with CKD. It has a profound influence on the quality of life of CKD patients, and its underlying causes are often associated with a negative prognosis. However, its pathophysiology is poorly understood. While hemodialysis may address fluid overload, it often does not significantly improve breathlessness, suggesting multiple and co‐existing alternative...

article

Noncystic Fibrosis Bronchiectasis

Sarah Svenningsen, Fumin Guo, David G. McCormack, Grace Parraga

Academic Radiology > 2017 > 24 > 1 > 4-12

Evidence-based treatment and management for patients with bronchiectasis remain challenging. There is a need for regional disease measurements as focal distribution of disease is common. Our objective was to evaluate the ability of magnetic resonance imaging (MRI) to detect regional ventilation impairment and response to airway clearance therapy (ACT) in patients with noncystic fibrosis (CF) bronchiectasis,...

article

Management of COPD: Is there a role for quantitative imaging?

Miranda Kirby, Edwin J.R. van Beek, Joon Beom Seo, Juergen Biederer, more

European Journal of Radiology > 2017 > 86 > C > 335-342

While the recent development of quantitative imaging methods have led to their increased use in the diagnosis and management of many chronic diseases, medical imaging still plays a limited role in the management of chronic obstructive pulmonary disease (COPD). In this review we highlight three pulmonary imaging modalities: computed tomography (CT), magnetic resonance imaging (MRI) and optical coherence...

article

Three-dimensional ultrasound measurements of carotid vessel wall and plaque thickness and their relationship with pulmonary abnormalities in ex-smokers without airflow limitation

Jieyu Cheng, Damien Pike, Tommy W. S. Chow, Miranda Kirby, more

The International Journal of Cardiovascular Imaging > 2016 > 32 > 9 > 1391-1402

The relationship between carotid disease and modestly abnormal airflow in ex-smokers without chronic obstructive pulmonary disease (COPD) is not well-understood. We generated 3D ultrasound measurements of carotid vessel-wall-plus-plaque thickness (VWT) and vessel wall volume (VWV) to quantify and evaluate such carotid ultrasound measurements in ex- and never-smokers without airflow limitation. These...

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INFONA - science communication portal

Search results for: Grace Parraga

Review of Hyperpolarized Pulmonary Functional ¹²⁹Xe MR for Long‐COVID

Review of Hyperpolarized Pulmonary Functional ¹²⁹Xe MR for Long‐COVID

Physical activity levels, pulmonary function, and MRI in children born extremely preterm: A comparison between children with and without bronchopulmonary dysplasia

Pulmonary MRI and Cluster Analysis Help Identify Novel Asthma Phenotypes

Pulmonary functional MRI: Detecting the structure–function pathologies that drive asthma symptoms and quality of life

Protocols for multi‐site trials using hyperpolarized ¹²⁹Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the ¹²⁹Xe MRI clinical trials consortium

Accelerated ¹²⁹Xe MRI morphometry of terminal airspace enlargement: Feasibility in volunteers and those with alpha‐1 antitrypsin deficiency

Rapid single‐breath hyperpolarized noble gas MRI‐based biomarkers of airspace enlargement

Rapid single‐breath hyperpolarized noble gas MRI‐based biomarkers of airspace enlargement

A framework for Fourier‐decomposition free‐breathing pulmonary ¹H MRI ventilation measurements

Hyperpolarized ³He MRI ventilatory apparent diffusion coefficient of alpha‐1 antitrypsin deficiency

On the Potential Role of MRI Biomarkers of COPD to Guide Bronchoscopic Lung Volume Reduction

Pulmonary MRI morphometry modeling of airspace enlargement in chronic obstructive pulmonary disease and alpha‐1 antitrypsin deficiency

Pulmonary 3He Magnetic Resonance Imaging Biomarkers of Regional Airspace Enlargement in Alpha-1 Antitrypsin Deficiency

Free-breathing Functional Pulmonary MRI

Ultrashort echo time MRI biomarkers of asthma

Why Is Your Patient Still Short of Breath? Understanding the Complex Pathophysiology of Dyspnea in Chronic Kidney Disease

Noncystic Fibrosis Bronchiectasis

Management of COPD: Is there a role for quantitative imaging?

Three-dimensional ultrasound measurements of carotid vessel wall and plaque thickness and their relationship with pulmonary abnormalities in ex-smokers without airflow limitation

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