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In the past decade, nanoparticles have been reported to show cellular toxicity. However, biophysical mechanism of the toxicity, such as uptake process of nanoparticles into a cell, is still unclear. In this study, we used an artificial cell, such as cell-seized liposomes, to clarify the physical mechanism of the interaction between nano/submicro particles and lipid bilayer membranes. First, we focused...
There are increasing many reports linking oxidation of the membrane to various diseases such as atherosclerosis. Using cell-sized (giant) unilamellar lipid vesicles, we studied the effect of exposing the lipid vesicles to an oxidative stress environment. We found that the vesicles underwent fluctuations, and some had morphological transformation. We characterized the main products of cholesterol oxidation...
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