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Significant heterogeneity in the tumor microenvironment of human cervical cancer patients is known to challenge treatment outcomes in this population. The current standard of care for cervical cancer patients is radiation therapy and concurrent cisplatin (CDDP) chemotherapy. Yet this treatment strategy fails to control loco-regional disease in 10–30% of patients. In order to improve the loco-regional...
Tumor heterogeneity is increasingly implicated in the limited therapeutic efficacy exerted by nanomedicines in vivo. Such heterogeneity is manifold – existing at macro- and microscopic scales, and subject to tumor differentiation, region, intervention, and time. Further, variable patient response to nano-based therapy has called into question the current pursuit, and practices, of nano-formulation...
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