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Symptoms of Parkinson's disease caused by dopamine depletion are associated with burst firing in the subthalamic nucleus (STN). Moreover, regularization or suppression of STN neuronal activity is thought to improve symptoms of Parkinson's disease. We reported recently that N-methyl-d-aspartate (NMDA) receptor stimulation of rat STN neurons evokes ATP-sensitive K + (K-ATP) current via a Ca...
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