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Rationale The role of serotonin (5-HT) on aggression has been extensively studied; nonetheless, the role of this neurotransmitter in aggression is still inconclusive. Objectives The current meta-analytical review investigated the role of increased 5-HT neurotransmission in aggression. Methods Preclinical studies using serotonin reuptake inhibitors, 5-hydroxytryptophan, l-tryptophan, or serotonin...
Rationale Atypical antipsychotics are commonly prescribed to clinically referred youngsters for treatment of heightened aggressive behavior associated with various psychiatric disorders. Previously, we demonstrated risperidone’s anti-aggressive effects using a well-validated animal model of offensive aggression. Paliperidone, the main active metabolite of risperidone, is a potent serotonin-2A and...
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