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Adenosine deaminases acting on RNA 1 (ADAR1) has been identified to play key roles in non‐small cell lung cancer (NSCLC) progression, and can modulate the sensitivity of cancer cells to anticancer drugs. The current study aimed to investigate the effect of ADAR1 on the sensitivity of NSCLC cells to anlotinib. We established anlotinib‐resistant NSCLC (NSCLC/AR) cells, including NCI‐H1975/AR and A549/AR...