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The physiological response of erythromycin fermentation scale-up from 50 L to 132 m3 scale was investigated. A relatively high oxygen uptake rate (OUR) in early phase of fermentation was beneficial for erythromycin biosynthesis. Correspondingly, the maximal consistency coefficient (K) reflecting non-Newtonian fluid characteristics in 50 L and 132 m3 fermenter also appeared in same phase. Fluid dynamics...
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