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A series of helicid analogues were prepared and evaluated in vitro for the cholinesterase (AChE and BuChE) inhibitory activities via UV spectroscopy. The results indicated that compounds 5, 6d and 8 exhibited potent AChE inhibitory activities with IC 50 values of 0.45±0.02μM, 0.49±0.02μM, and 0.20±0.01μM, respectively. High selectivity for AChE over BuChE was also observed. Kinetic study showed...
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