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Polycythemia vera (PV) is characterized by erythrocytosis associated with the presence of the activating JAK2 V617F mutation in a variable proportion of hematopoietic cells. JAK2 V617F is detected in other myeloproliferative neoplasms, does not appear to be the PV-initiating event, and its specific role in deregulated erythropoiesis in PV is incompletely understood. We investigated...
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