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Chronic disease management currently requires frequent withdrawal of bodily fluids to assess biomolecule levels and are associated with patient discomfort and noncompliance. Thus, a need exists for less invasive, on-demand biochemistry monitoring. Our lab has investigated poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels functionalized with glucose oxidase and palladium benzoporphyrin phosphors...
Ratiometric luminescent microparticle sensors have been developed for sensing biochemical targets such as glucose in interstitial fluid, enabling use of dermal implants for on-demand monitoring. For these sensor systems to be deployed in vivo, a matched optoelectronic system for interrogation of dermally-implanted sensors was previously designed, constructed, and evaluated experimentally. During evaluation...
Enzymatic glucose sensors based on luminescent microparticles rely on the reaction of glucose and oxygen with glucose oxidase, where the internal oxygen level is transduced via oxygen-sensitive phosphors. These sensors utilize nanofilm coatings comprising polyelectrolyte multilayers deposited using self-assembly to control transport of glucose, enabling tuning of the range and sensitivity by changing...
This chapter contains sections titled:
Introduction
Overview of Fluorescence‐Based Glucose Assays
Transduction Methods and Materials
Packaging for In Vivo use
Ongoing Commercialization Activities
Summary/Concluding Remarks
References
Luminescence-based sensors have been developed in microparticle formats for biochemical targets such as glucose, enabling use of dermal implants for on-demand monitoring. For these to be deployed and interrogated in vivo, a matched optoelectronic system for delivery of excitation, collection and analysis of luminescence response is needed. In this work, simulations based on Monte Carlo ray-tracing...
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