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Fossil rodents are generally scarce in the Miocene of Japan. However, as much as three taxa of eomyid rodents had been reported from the early Miocene Nakamura Formation (ca. 18.5 Ma) in Gifu Prefecture, central Japan. In this study, we revisit one of them—the small-sized taxon—and assign this material to a new genus, Japaneomys, which is so far known only from the type locality. The new genus is...
The tight junction protein claudin-4 is frequently overexpressed in pancreatic cancer, and is also a receptor for Clostridium perfringens enterotoxin (CPE). The cytotoxic effects of CPE are thought to be useful as a novel therapeutic tool for pancreatic cancer. However, the responses to CPE via claudin-4 remain unknown in normal human pancreatic duct epithelial (HPDE) cells. We introduced the human...
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