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In this study, ON and OFF retinal ganglion cell (RGC) models based on accurate biophysics and realistic representations of cell morphologies were used to understand how these cells selectively respond to high-frequency electrical stimulation (HFS). With optimized model parameters and the incorporation of detailed cell morphologies, these two models were able to closely replicate experimental ON and...
Retinal ganglion cells (RGCs) demonstrate a large range of variation in their ionic channel properties and morphologies. These cell-specific properties are responsible for the unique way they process synaptic inputs. A cell-specific modeling approach allows us to examine the functional significance of regional membrane channel expression and cell morphology. ON and OFF RGC models based on accurate...
A cardiac sino-atrial tissue model based on a simplified 2D disc geometry and a generic ionic model is described and optimized to fit intact-tissue microelectrode experimental recordings. Concentric regions were defined representing the central and peripheral sino-atrial node and the atrium, each with a unique set of ionic model parameters. Intracellular action potentials were recorded from the respective...
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