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Background and AimHeparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) has a proliferative effect on several types of cells. However, the role of HB‐EGF on hepatic stellate cells (HSCs) is not clear. The present study is to investigate the regulatory effects of HB‐EGF on HSC proliferation and apoptosis.
MethodsActivated primary rat HSCs and two HSC cell lines (human LX2 and rat T6)...
Pentoxifylline (PTX), which is a xanthine derivative, is a well‐known suppressor of tumor necrosis factor‐alpha (TNF‐alpha) production in inflammatory cells and has also been shown to inhibit collagen synthesis in hepatic stellate cells (HSCs) in vitro. The present study aimed to evaluate the effects of PTX on proliferation in HSCs as mediated by the Raf/MEK/extracellular‐signal‐regulated kinase (ERK)...
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