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Fluoxetine is a safe antidepressant with remarkable anti‐inflammatory actions; therefore, we aimed to investigate its effects on immortalized (HaCaT) as well as primary human epidermal keratinocytes in a polyinosinic‐polycytidylic acid (p(I:C))‐induced inflammatory model. We found that a non‐cytotoxic concentration (MTT‐assay, CyQUANT‐assay) of fluoxetine significantly suppressed p(I:C)‐induced expression...
Background
The identification of biomarkers correlated with coronavirus disease 2019 (COVID‐19) outcomes is a relevant need for clinical management. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is characterized by elevated interleukin (IL)‐6, IL‐10, HLA‐G, and impaired testosterone production.
Objectives
We aimed at defining the combined impact of sex hormones, interleukin‐10,...
Background
Male patients with COVID‐19 have been found with reduced serum total testosterone (tT) levels and with more severe clinical outcomes.
Objectives
To assess total testosterone (tT) levels and the probability of recovering eugonadal tT levels during a minimum 12‐month timespan in a cohort of men who have been followed over time after the recovery from laboratory‐confirmed COVID‐19.
Materials...
Background
Although over 5000 platelet transfusions occur daily in the United States, the presence of SARS‐CoV‐2 antibodies in platelet units is not commonly evaluated for. The effects of platelet transfusions with SARS‐CoV‐2 antibodies remain largely unknown. We evaluated single‐donor (apheresis) platelet units for SARS‐CoV‐2 antibodies and determined if platelet transfusions passively transferred...
Background
Circulating testosterone levels have been found to be reduced in men with severe acute respiratory syndrome coronavirus 2 infection, COVID‐19, with lower levels being associated with more severe clinical outcomes.
Objectives
We aimed to assess total testosterone levels and the prevalence of total testosterone still suggesting for hypogonadism at 7‐month follow‐up in a cohort of 121 men...
Background
Circulating androgens could have a relevant pathobiological role in clinical outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection (COVID‐19).
Objectives
We aimed to assess: (a) circulating sex steroids levels in a cohort of 286 symptomatic men with laboratory‐confirmed COVID‐19 at hospital admission compared to a cohort of 281 healthy men; and (b)...
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