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Two isolates each of Candida albicans, Candida tropicalis,and Candida glabrata were selected for time-kill curve testing against LY 303366 at concentrations ranging from 0.125 MIC to 16 MIC. RPMI 1640 buffered with morpholinepropanesulfonic acid (MOPS) was utilized as growth medium. Samples were obtained at predetermined time points over 24 hours and streaked for colony count determination...
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