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Multiple cortical and subcortical regions have been shown to exhibit altered transcriptional states in association with schizophrenia (SZ) through gene expression studies. Select nuclei of the thalamus, a subcortical region, have been previously shown to have neuron and volume loss. These thalamic regions are reciprocally connected with areas of cortex which have been implicated in SZ. The thalamic...
Growth-associated protein 43 (GAP-43) was critical for initial establishment or reorganization of synaptic connections, a process thought to be disrupted in schizophrenia. Abnormal GAP-43 expression has been linked to this disorder in numerous postmortem brain studies. The purpose of this study was to investigate the involvement of the gene encoding GAP-43 in the susceptibility to schizophrenia.We...
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