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Cell cycle is controlled at two restriction points, R1 and R2. At both points the cell will commit apoptosis if it detects irreparable damage. But at R1 an undamaged cell also decides whether to proceed to the S phase or go into a quiescent mode, depending on the environmental conditions (e.g., overpopulation, hypoxia). We consider the effect of this decision at the population level in a spherical...
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