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Depleted uranium (DU) has been widely used in both civilian and military activities, and the kidney is the main target organ of DU during acute high-dose exposures. In this study, the nephrotoxicity caused by DU in metallothionein-1/2-null mice (MT−/−) and corresponding wild-type (MT+/+) mice was investigated to determine any associations with MT. Each MT−/− or MT+/+ mouse was pretreated with a single...
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