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BackgroundAlterations in the NOTCH1 signaling pathway are found in about 60% of pediatric T‐ALL, but its impact on prognosis remains unclear.
ProcedureWe extended the previously published CoALL cohort (n = 74) to a larger cohort (n = 127) and additionally included 38 Argentine patients from ALL IC‐BFM to potentially identify novel mutations and decipher a stronger discriminatory effect on the genotype/phenotype...
In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease‐specific first‐line clinical trials or interim registries. Essential components are a pediatric cancer registry and centralized reference laboratories, imaging review, and tumor board assistance. The five‐year overall survival rate in countries where such infrastructures are established has improved...
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