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Hypoxia inducible factor (HIF)−1α could be stabilized by Grx1 deletion, which is implicated critical in the pathogenesis of bronchopulmonary dysplasia (BPD). Until now, the stabilization of HIF‐1α by glutathionylation to regulate the pulmonary microcirculation in BPD is not well addressed. In this study, we investigated whether the HIF‐1α stabilization modulated by Grx1 ablation could ameliorate the...
The pathogenesis of necrotizing enterocolitis (NEC) is severe inflammatory injury in preterm infants, which resulted from macrophage polarization. Nuclear factor‐κB (NF‐κB) is implicated to be involved in macrophage polarization. We here evaluated the essential role of NF‐κB in macrophage polarization in NEC in human samples from neonates with NEC and the mouse experimental NEC model. Enhanced intestinal...
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