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The rat connexin40 gap junction channel is permeable to monovalent cations including tetramethylammonium and tetraethylammonium ions. Larger tetraalkyammonium (TAA+) ions beginning with tetrabutylammonium (TBA+) reduced KCl junctional currents disproportionately. Ionic blockade by tetrapentylammonium (TPeA+) and tetrahexylammonium (THxA+) ions were concentration- and voltage-dependent and occurred...
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