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While our previous work has shown that replacing existing vaccines with thermostable vaccines can relieve bottlenecks in vaccine supply chains and thus increase vaccine availability, the question remains whether this benefit would outweigh the additional cost of thermostable formulations.Using HERMES simulation models of the vaccine supply chains for the Republic of Benin, the state of Bihar (India),...
Although mass drug administration (MDA) has helped reduce morbidity attributed to soil-transmitted helminth infections in children, its limitations for hookworm infection have motivated the development of a human hookworm vaccine to both improve morbidity control and ultimately help block hookworm transmission leading to elimination. However, the potential economic and epidemiologic impact of a preventive...
Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae...
This paper contains a mathematical demonstration of some new aspects of Fixed Charges comprised of three most significant and interrelated components, namely: return, depreciation, and taxes which depend directly on such return and on the treatment accorded depreciation in their computations. Such mathematical demonstration is culminated in a set of new general formulas for determining levelized annual...
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