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Centrality-lethality rule demonstrates that proteins with high degree in the protein-protein interaction (PPI) network are more likely to be essential than those selected by chance. Nevertheless, in PPI network, there are still many proteins with high degree are not essential (false hubs). Comparing the difference between false hubs and essential hubs from topological perspective, such as centrality...
In the analysis of Protein-Protein Interaction (PPI) network, one intriguing problem is the reason for centrality-lethality rule. To discover the relationship between topological properties and functional features of proteins in PPI network, we classified hub proteins into two types: essential hub and nonessential hub and combined proteins' topological structure and evolutionary rate information together...
One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub...
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