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Higher plants utilize nucleotide‐binding leucine‐rich repeat domain proteins (NLRs) as intracellular immune receptors to recognize pathogen‐derived effectors and trigger a robust defense. The Activated Disease Resistance 1 (ADR1) family of coiled‐coil NLRs (CNLs) have evolved as helper NLRs that function downstream of many TIR‐type sensor NLRs (TNLs). Close homologs of ADR1s form the N REQUIREMENT...
Nucleotide‐binding leucine‐rich repeat proteins (NLRs) serve as intracellular immune receptors in animals and plants. Sensor NLRs perceive pathogen‐derived effector molecules and trigger robust host defense. Recent studies revealed the role of three coiled‐coil‐type NLRs (CNLs) of the ADR1 family – ADR1, ADR1‐L1 and ADR1‐L2 – as redundant helper NLRs, whose function is required for defense mediated...
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