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CYP2D6 plays a major role in the metabolism of tamoxifen, and polymorphism of P-glycoprotein has been associated with resistance of many drug therapies. This study investigates the clinical impact of genetic variants of CYP2D6 and ABCB1 in breast cancer patients treated with tamoxifen. Blood samples from 95 breast cancer patients treated with tamoxifen were collected and genotyped for CYP2D6...
The present study investigated the dependence of various mechanical and fracture properties on the volume fraction, φf, of the reinforcing glass fibres in Polycarbonate/Acylonitrile Butadiene Styrene (ABS) blends. The addition of glass fibres enhanced the ultimate tensile strength and modulus and reduced elongation (both to yield and to break) and total work of fracture. The elastic modulus was not...
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