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Trans‐activating transcriptional activator (TAT), a cell‐penetrating peptide, is extensively used for facilitating cellular uptake and nuclear targeting of drug delivery systems. However, the positively charged TAT peptide strongly interacts with serum components and undergoes substantial phagocytosis by the reticuloendothelial system, causing a short blood circulation in vivo. In this work, an acid‐active...
In article number 1705436, Shaobing Zhou, Zi Chen, and co‐workers develop an acid‐active tumor‐targeting nanoplatform with self‐reported drug‐release capability. This platform has unique features, such as a long blood circulation through shielding of the cationic charges of trans‐activating transcriptional activator (TAT), an enhanced cellular internalization by regenerating the original TAT in acidic...
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