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Ovarian cancer is the leading cause of death in gynecological cancers. Carboplatinum-based therapy is the standard treatment choice for ovarian cancer. However, a majority of the patients develop resistance to carboplatinum fairly rapidly hence there is a clinical need for early predictors of carboplatinum resistance. While there are a few indicative gene markers, they have poor sensitivity and specificity...
Post-translational modifications pegged on to the N-terminal tails of the nucleosomes core histone proteins determine the transcriptional activity of that chromosomal region leading to the histone code hypothesis. We rely on recently produced experimental data on genome-wide maps of chromatin state to derive computational models delineating the hidden patterns of post-translational modifications....
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