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We have explored correlations between the measured efficiency of the RNAi process and several computed signatures that characterize equilibrium secondary structure of the participating mRNA, siRNA, and their complexes. A previously published data set of 609 experimental points (with efficiency represented as percentage of remaining mRNA) was used for the analysis. While virtually no correlation with...
Protein-based computers are ripe for spectacular scientific advances because we know a great deal about these circuits' molecular components. But we are only beginning to understand how they process information and make decisions. Of the many types of information processing systems known to us, the least well understood are the complex, intracellular molecular reaction networks that control the physiology...
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