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Objectives: The aim of this study was to investigate the characteristics of fetal sheep resistance vessel responses to endogenous vasoactive agents in vitro. The contractile responses to potassium (K) and norepinephrine (NE), and the relaxation responses to acetylcholine (ACh) and bradykinin (BK) were examined.Methods: Skeletal muscle arteries of 0.6 and 0.9 gestation (G) fetal sheep were mounted...
Maternal undernutrition may produce an adverse intrauterine environment, altering development of fetal tissues and organs. We have previously shown that only a modest level of maternal undernutrition in early gestation is capable of blunting responses of the fetal Hypothalamic Pituitary Adrenal (HPA) axis to exogenous stimulation. To assess the effect on fetal responses to a physiological stress...
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