Search results for: C. Becker

Items from 1 to 20 out of 1,180 results

article

Flavour improvement in early generations of fresh market tomatoes (Solanum lycopersicum L.): II. Response to breeders' sensory and marker‐assisted selection

Julia Hagenguth, Larissa Kanski, Hannah Kahle, Heiko C. Becker, more

Fresh market tomatoes are often characterized by poor flavour. Flavour is a quantitative trait difficult to assess and often neglected in breeding. Classical sensory methods are not suitable for the evaluation of early segregating generations; simple physicochemical measurements are not sufficient to predict perceived aroma. Alternative selection methods are needed, such as the recently introduced...

article

Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases

Thibault Kervarrec, Danna Westphal, Daniel Pissaloux, Mélanie Legrand, more

Histopathology > 85 > 4 > 566 - 578

Aims Porocarcinoma is a malignant sweat gland tumour differentiated toward the upper part of the sweat duct and may arise from the transformation of a preexisting benign poroma. In 2019, Sekine et al. demonstrated the presence of YAP1::MAML2 and YAP1::NUTM1 fusions in most poromas and porocarcinomas. Recently, our group identified PAK2‐fusions in a subset of benign poromas. Herein we report a series...

article

West Nile and Usutu viruses are efficiently inactivated in platelet concentrates by UVC light using the THERAFLEX UV‐Platelets system

Ute Gravemann, Mathias Boelke, Laura Könenkamp, Lars Söder, more

Vox Sanguinis > 119 > 8 > 827 - 833

Background and Objectives West Nile virus (WNV) and Usutu virus (USUV) are mosquito‐borne flaviviruses (Flaviviridae) that originated in Africa, have expanded their geographical range during the last decades and caused documented infections in Europe in the last years. Acute WNV and USUV infections have been detected in asymptomatic blood donors by nucleic acid testing. Thus, inactivation of both...

article

Analyses of combined Merkel cell carcinomas with neuroblastic components suggests that loss of T antigen expression in Merkel cell carcinoma may result in cell cycle arrest and neuroblastic transdifferentiation

Thibault Kervarrec, Silke Appenzeller, Susanne Gramlich, Etienne Coyaud, more

The Journal of Pathology > 264 > 1 > 112 - 124

Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by genomic integration of the Merkel cell polyomavirus (MCPyV). MCPyV‐negative cases often present as combined MCCs, which represent a distinctive subset of tumors characterized by association of an MCC with a second tumor component, mostly squamous cell carcinoma. Up to now, only exceptional cases of combined MCC with neuroblastic...

article

Merkel cell polyomavirus pan‐T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1

Kuan Cheok Lei, Nalini Srinivas, Mitalee Chandra, Thibault Kervarrec, more

Journal of Medical Virology > 96 > 7 > n/a - n/a

Merkel cell carcinoma (MCC) is a highly aggressive skin cancer associated with integration of Merkel cell polyomavirus (MCPyV). MCPyV‐encoded T‐antigens (TAs) are pivotal for sustaining MCC's oncogenic phenotype, i.e., repression of TAs results in reactivation of the RB pathway and subsequent cell cycle arrest. However, the MCC cell line LoKe, characterized by a homozygous loss of the RB1 gene, exhibits...

article

Non‐invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement

G. Condous, B. Gerges, I. Thomassin‐Naggara, C. Becker, more

Ultrasound in Obstetrics & Gynecology > 64 > 1 > 129 - 144

The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), the European Society of Human Reproduction and Embryology (ESHRE), the International Society for Gynecologic Endoscopy (ISGE), the American Association of Gynecologic...

article

Effect of full‐sib and S2‐selection on a sweet corn population (Zea mays convar. saccharata)

Charlotte Aichholz, Heiko C. Becker, Bernd Horneburg

Plant Breeding > 143 > 3 > 385 - 402

Sweet corn breeding goals differ from grain or silage corn. Sweet corn goals focus on marketable yield including several quality traits. This study explores the effect of a single cycle of full‐sib selection and S2 selection on improving the marketable yield of an open‐pollinated sweet corn population. The selected populations were subsequently compared in four environments for several plant‐, yield‐...

article

Flavour improvement in early generations of fresh market tomatoes (Solanum lycopersicum): I. Identification of QTL for sensory attributes, physicochemical measurements and volatile compounds

Julia Hagenguth, Larissa Kanski, Hannah Kahle, Heiko C. Becker, more

Plant Breeding > 143 > 3 > 334 - 349

Human sensory analysis is the most appropriate method for assessing the flavour of fresh market tomatoes, but it is very labour and time consuming. Therefore, sensory attributes are often neglected in early generations of breeding programmes and genetic studies, although there is a demand for tomatoes with improved flavour. In this study, the recently developed Breeders' Sensory Test was applied to...

article

Microorganisms uniquely capture and predict stony coral tissue loss disease and hurricane disturbance impacts on US Virgin Island reefs

Cynthia C. Becker, Laura Weber, Joel K. Llopiz, T. Aran Mooney, more

Environmental Microbiology > 26 > 4 > n/a - n/a

Coral reef ecosystems are now commonly affected by major climate and disease disturbances. Disturbance impacts are typically recorded using reef benthic cover, but this may be less reflective of other ecosystem processes. To explore the potential for reef water‐based disturbance indicators, we conducted a 7‐year time series on US Virgin Island reefs where we examined benthic cover and reef water nutrients...

article

Application of model updating to a large‐scale hybrid simulation

Mao Cheng, Maria Camila Lopez Ruiz, Tracy C. Becker

Earthquake Engineering & Structural Dynamics > 53 > 3 > 1398 - 1415

Model updating can enhance hybrid simulation by utilizing the experimental data from the physically tested substructure to update the parameters of like‐components in the numerical substructure throughout the test, improving the overall accuracy and reducing the extent of the experimental setup. Identifying and updating parameters can be challenging, especially when coupling between degrees of freedom...

article

Combined immunotherapy with ipilimumab plus nivolumab in metastatic PD‐1/PD‐L1‐refractory Merkel cell carcinoma—a case report

Anna‐Sophia Leven, Jürgen C. Becker, Christoph Pöttgen, Dirk Schadendorf, more

International Journal of Dermatology > 63 > 2 > e69 - e71

article

(Not so) powerful allies? Decision makers’ reactions to advantaged group allies in collective action

Lea Hartwich, Maja Kutlaca, Inna Ksenofontov, Jolanda Jetten, more

European Journal of Social Psychology > 53 > 7 > 1576 - 1592

Do allies in collective action have a positive impact on political efficacy? Theoretical considerations and common sense might lead us to expect that advantaged group allies will be beneficial to the success of social movements. However, across five experimental studies, with samples from the United States and Germany (three pre‐registered, total N = 696, 48% women, M_age = 38), we find that such involvement...

article

S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“ – update 2023, part 2: epidemiology and etiology, diagnostics, surgical and systemic treatment of cutaneous squamous cell carcinoma (cSCC), surveillance and prevention

Ulrike Leiter, Markus V. Heppt, Theresa Steeb, Mareike Alter, more

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 21 > 11 > 1422 - 1433

Actinic keratosis (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence‐based framework for clinical decision making, the guideline “actinic keratosis and cutaneous squamous...

article

S3‐Leitlinie “Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Update 2023, Teil 2: Epidemiologie und Ätiologie, Diagnostik, Therapie des invasiven Plattenepithelkarzinoms der Haut, Nachsorge und Prävention

Ulrike Leiter, Markus V. Heppt, Theresa Steeb, Mareike Alter, more

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 21 > 11 > 1422 - 1434

Aktinische Keratosen (AK) sind häufige Hautveränderungen bei hellhäutigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) überzugehen. Beide Erkrankungen können mit erheblicher Morbidität verbunden sein und stellen eine große Krankheitslast insbesondere in der älteren Bevölkerung dar. Um einen evidenzbasierten Rahmen für die klinische Entscheidungsfindung zu schaffen, wurde...

article

Changes in opioid prescribing in veterans with headache during the COVID‐19 pandemic: A regression discontinuity in time analysis

Kaicheng Wang, Brenda T. Fenton, Melissa Skanderson, Anne C. Black, more

Headache: The Journal of Head and Face Pain > 63 > 9 > 1295 - 1303

Objective To determine changes in opioid prescribing among veterans with headaches during the coronavirus disease of 2019 (COVID‐19) pandemic by comparing the stay‐at‐home phase (March 15 to May 30, 2020) and the reopening phase (May 31 to December 31, 2020). Background Opioid prescribing for chronic pain has declined substantially since 2016; however, changes in opioid prescribing during the COVID‐19...

article

S2k Guideline – Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) – Update 2022

Jürgen C. Becker, Ambros J. Beer, Viola K. DeTemple, Thomas Eigentler, more

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 21 > 3 > 305 - 320

Merkel cell carcinoma (MCC, ICD‐O M8247/3) is a rare, malignant, primary skin tumor with epithelial and neuroendocrine differentiation. The tumor cells share many morphologic, immunohistochemical, and ultrastructural features with cutaneous Merkel cells. Nevertheless, the cell of origin of MCC is unclear. MCC appears clinically as a reddish to purple spherical tumor with a smooth, shiny surface and...

article

S2k‐Leitlinie – Merkelzellkarzinom – Update 2022

Jürgen C. Becker, Ambros J. Beer, Viola K. DeTemple, Thomas Eigentler, more

JDDG: Journal der Deutschen Dermatologischen Gesellschaft > 21 > 3 > 305 - 317

Das Merkelzellkarzinom (MCC, ICD‐O M8247/3) ist ein seltener, maligner, primärer Hauttumor mit epithelialer und neuroendokriner Differenzierung. Die Tumorzellen teilen viele morphologische, immunhistochemische und ultrastrukturelle Eigenschaften mit den Merkel‐Zellen der Haut. Die Ursprungszelle (cell of origin) des MCC ist dennoch unklar. Das MCC imponiert klinisch als ein rötlich bis violett farbiger...

article

Supporting men or male privilege? Women's progressive and reactionary collective action for men

Gosia Mikołajczak, Julia C. Becker

European Journal of Social Psychology > 52 > 7 > 1064 - 1081

Collective action for other groups, such as men's action for women, has usually been analysed as social protest advancing equality of disadvantaged groups. In the current research we extend collective action literature by applying SIMCA predictors—identity, injustice, efficacy—to investigate action in support of an advantaged group (women's action for men) and by distinguishing its progressive and...

article

Low system justification is associated with support for both progressive and reactionary social change

Luisa Liekefett, Julia C. Becker

European Journal of Social Psychology > 52 > 7 > 1015 - 1030

Traditional definitions of political ideology state that right‐wingers support system stability, whereas left‐wingers support social change. However, during the last decade many right‐wing movements have been on the rise and demanded far‐reaching changes. We argue that both left‐, and right‐wing protestors reject the status quo, and are motivated to change it – albeit in opposing directions: either...

article

Joint longitudinal trajectories of pain intensity and opioid prescription in veterans with back pain

Eugenia Buta, Kirsha S. Gordon, Ralitza Gueorguieva, William C. Becker, more

Pharmacoepidemiology and Drug Safety > 31 > 12 > 1262 - 1271

Purpose We describe pain intensity and opioid prescription jointly over time in Veterans with back pain to better understand their relationship. Methods We performed a retrospective cohort study on electronic health record data from 117 126 Veterans (mean age 49.2 years) diagnosed with back pain in 2015. We used latent class growth analysis to jointly model pain intensity (0–10 scores) and opioid...

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INFONA - science communication portal

Search results for: C. Becker

Flavour improvement in early generations of fresh market tomatoes (Solanum lycopersicum L.): II. Response to breeders' sensory and marker‐assisted selection

Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases

West Nile and Usutu viruses are efficiently inactivated in platelet concentrates by UVC light using the THERAFLEX UV‐Platelets system

Analyses of combined Merkel cell carcinomas with neuroblastic components suggests that loss of T antigen expression in Merkel cell carcinoma may result in cell cycle arrest and neuroblastic transdifferentiation

Merkel cell polyomavirus pan‐T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1

Non‐invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement

Effect of full‐sib and S2‐selection on a sweet corn population (Zea mays convar. saccharata)

Flavour improvement in early generations of fresh market tomatoes (Solanum lycopersicum): I. Identification of QTL for sensory attributes, physicochemical measurements and volatile compounds

Microorganisms uniquely capture and predict stony coral tissue loss disease and hurricane disturbance impacts on US Virgin Island reefs

Application of model updating to a large‐scale hybrid simulation

Combined immunotherapy with ipilimumab plus nivolumab in metastatic PD‐1/PD‐L1‐refractory Merkel cell carcinoma—a case report

(Not so) powerful allies? Decision makers’ reactions to advantaged group allies in collective action

S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“ – update 2023, part 2: epidemiology and etiology, diagnostics, surgical and systemic treatment of cutaneous squamous cell carcinoma (cSCC), surveillance and prevention

S3‐Leitlinie “Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Update 2023, Teil 2: Epidemiologie und Ätiologie, Diagnostik, Therapie des invasiven Plattenepithelkarzinoms der Haut, Nachsorge und Prävention

Changes in opioid prescribing in veterans with headache during the COVID‐19 pandemic: A regression discontinuity in time analysis

S2k Guideline – Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) – Update 2022

S2k‐Leitlinie – Merkelzellkarzinom – Update 2022

Supporting men or male privilege? Women's progressive and reactionary collective action for men

Low system justification is associated with support for both progressive and reactionary social change

Joint longitudinal trajectories of pain intensity and opioid prescription in veterans with back pain

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