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The combination of key structural pharmacophores found in known leukotriene D 4 (LTD 4 ) receptor antagonists with those of potent platelet activating factor (PAF) receptor antagonist UK-74,505 has led to the synthesis of hybrid compounds CP-96,021 and CP-96,486. These compounds represent the first known balanced, combined and orally active LTD 4 /PAF receptor antagonists.
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