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Preliminary experiments showed that MC-1 magnetotactic bacteria (MTB) could be used for the delivery of therapeutic agents to tumoral lesions. Each bacterium can provide a significant thrust propulsion force generated by two flagella bundles exceeding 4pN. Furthermore, a chain of single-domain magnetosomes embedded in the cell allows computer directional control and tracking using a magnetic resonance...
In magnetic resonance imaging (MRI), the susceptibility-based contrast provides a way to amplify the effects of a magnetic microparticle, whereas its volume is largely inferior to the spatial resolution of the system. This concept presents an approach to visualization by means of susceptibility artifact using ferromagnetic microparticles. In this work, the amount of the susceptibility artifact was...
Our group has previously demonstrated that magnetic nanoparticles (MNP) embedded in microrobots can be used for propulsion and tracking in the human vascular network while being guided by an MRI platform. Here, we show that the same magnetic nanoparticles can also be exploited to perform various functions including but not limited to hyperthermic drug release actuators. Specifically, we synthesized...
Bacteria can be used as computer-controlled bioactuators and means of propulsion for microrobots and other micro-scaled entities to accomplish precise operations as first proposed by our research group in [1] and demonstrated later experimentally in [2]. The last reference confirmed that the propulsion force provided by the flagella being connected to molecular motors embedded in the bacterial cell,...
A real-time positioning and tracking technique for untethered devices or robots magnetically propelled by a clinical magnetic resonance imaging (MRI) system is described. The local magnetic field induced by the device, composed of a ferromagnetic material, is used as a signature to localize the device on three one-dimensional projections. A high-precision 3D circular-motion system was used to assess...
The use of a clinical MRI system for propelling and controlling the displacement of a ferromagnetic core along a pre-planned path in the blood vessels has been validated experimentally by our group. The results of the experiment suggest that a MRI platform could not only be used as an imaging or diagnostic tool, but also as an interventional platform. One important medical intervention where such...
A MEMS structure based on standard CMOS process is presented. It consists in the fabrication of micro-reservoirs in which will be embedded magnetotactic bacteria (MTB) to form a propulsion system for a 550 mum x 650 mum fully autonomous micro- robot to be operated in an aqueous medium. Due to magnetotaxis inherent in each bacterium, the motility of the MTB can be exploited. Furthermore, a directional...
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