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Preliminary experiments showed that MC-1 magnetotactic bacteria (MTB) could be used for the delivery of therapeutic agents to tumoral lesions. Each bacterium can provide a significant thrust propulsion force generated by two flagella bundles exceeding 4pN. Furthermore, a chain of single-domain magnetosomes embedded in the cell allows computer directional control and tracking using a magnetic resonance...
The paper describes the choice of a thermoresponsive material for the implementation of untethered medical microrobots and other microdevices. These entities can be propelled at a specific location in the body using a Magnetic Resonance Imaging (MRI) system while being actuated for various functions such as the release of drugs by a volume change induced by hyperthermia of nanoparticles embedded in...
The use of a clinical MRI system for propelling and controlling the displacement of a ferromagnetic core along a pre-planned path in the blood vessels has been validated experimentally by our group. The results of the experiment suggest that a MRI platform could not only be used as an imaging or diagnostic tool, but also as an interventional platform. One important medical intervention where such...
Magnetic resonance imaging (MRI) scanners can be used with minimum upgrades as integrated platforms for targeted delivery of micro/nanoparticles in the human body. In addition to being widespread in hospitals, they provide real-time tracking, control and means of propulsion for magnetic devices without penetration depth limitations. From these positive features, MRI appears as the perfect central...
Magnetic resonance imaging characteristics of novel potential drug delivery agents are investigated. Candidate carriers considered in this study are iron-cobalt (Fe-Co) nanoparticles, magnetotactic bacteria (MTB), and magnetite (Fe3O4) microparticles. The micro and nanoparticles are highly magnetic and can be steered using gradient coils. MTB, on the other hand, are microorganisms that naturally follow...
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