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Microgravity induces significant and progressive bone loss in both humans and animals. This is the consequence of disturbed bone remodeling. We performed a bed rest experiment to simulate microgravity and tried to clarify bone metabolism by measuring biochemical markers of bone turnover. Six healthy volunteers participated in 120 days of bed rest. The parameters of calcium homeostasis, calcitropic...
Bone loss during space flight may be induced by decreased activity of bone formation. To explore a new method for the bone loss in microgravity, the effects of insulin-like growth factor I (IGF-I), a potent stimulator for osteoblast activities, were studied in in vitro and in vivo system. The complex of IGF-I and its specific binding protein, IGFBP-3, may stimulate the osteoblastic activities via...
The expression of insulin-like growth factor-I (IGF-I), interleukin-6 (IL-6), and transforming growth factor-β 1 (TGF-β 1 ) mRNA in rat femurs was examined following marrow ablation. Northern blot analysis showed multiple transcripts of IGF-I, a major transcript of 1.3 kb and a minor one of 2.4 kb for IL-6 and a single band of 2.5 kb for TGF-β 1 , respectively. Examination...
Recombinant human growth/differentiation factor 5 (huGDF5) was examined for its biological properties; brachypodism mice have already been reported to show mutations in the gene. Our experiments demonstrated that recombinant huGDF5 stimulated in vitro mesenchymal aggregation and chondrogenesis in rat limb bud cells. In vivo, partially purified huGDF5 induced cartilage and bone formation in muscular...
In this study, we investigated age-related changes in serum levels of both the carboxyterminal propeptide of type I procollagen (PICP) and the pyridinoline crosslinked telopeptide of type I collagen (ICTP) to elucidate bone formation and resorption, respectively, in 200 normal Japanese children (141 males and 59 females, age range 0-16 years). Furthermore, to clarify the effect of GH on bone turnover,...
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