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Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) encodes a G protein-coupled receptor (vGPCR) in open reading frame (ORF) 74, which is homologous to human chemokine receptors. KSHV vGPCR is constitutively active and induces VEGF-mediated angiogenesis. Previous studies have shown that ORF 74 is transcribed as part of a bicistronic message containing ORF K14 upstream of ORF 74, with an early lytic...
Primary effusion lymphoma (PEL) is a rare and distinctive type of B-cell non-Hodgkin's lymphoma (NHL) that occurs primarily, although not exclusively, in patients with AIDS. It usually develops as a lymphomatous effusion in the absence of a tumor mass, characteristically contains the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8), usually also contains the Epstein-Barr virus...
Background: Two novel nonhuman DNA fragments were discovered in an AIDS-related Kaposi's sarcoma (KS) lesion using representational difference analysis. Design: These sequences belong to a previously unidentifiedgamma-2-herpesvirus exhibiting homology with Herpesvirus saimiri and Epstein–Barr virus. This virus was named Kaposi'ssarcoma–associated herpesvirus (KSHV) and provisionally designated human...
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