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Theophylline tablets were prepared using waxy maize starch gels and the effect of retrogradation on the release of theophylline was investigated. Slurries of starch and theophylline were autoclaved in a polypropylene tablet mold and then stored at 4°C or cycled at 4/30°C for 8days. By increasing the period of retrogradation at 4°C the size of air cells in freeze-dried gels was decreased and the cell...
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