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Rationale The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy have not been well demonstrated. Objectives The purpose of the study was to evaluate...
AbstractRationale: Selective drugs are required to test the hypothesis whether antipsychotic effects may be induced or modulated by 5HT2A receptor antagonism. M100907 (previously known as MDL 100,907) is a highly selective 5HT2A antagonist in clinical development. Objective: To test if the suggested clinical dose of 20 mg M100907 daily induces high 5HT2A receptor occupancy in patients with schizophrenia...
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