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Tropomyosins are coiled-coil dimers that bind to the major groove of F-actin and regulate its accessibility to actin-modifying proteins. Although approximately 40 tropomyosin isoforms have been identified in mammals, they can broadly be classified into two groups based on protein size, that is, high molecular weight and low molecular weight isoforms. Osteoclasts, which undergo rounds of polarization...
Osteoclasts resorb bone through transient rearrangement of their cytoskeletons to create a polarized phenotype in which an apical ruffled membrane is surrounded by a ring of F-actin that creates a tight seal against bone substrate. This process, coupled with the capacity for rapid motility, necessitates the presence of a dynamic, multi-functional actin cytoskeleton. Tropomyosins are a large class...
The effect of oestrogen status on BMD in 77 healthy women aged 45-54 was examined by classifying them according to their FSH concentrations. 47 were classified as premenopausal (mean FSH 6.36 ± 2.1 iu/l), 26 were perimenopausal (mean FSH 22.8 ± 14.2 iu/l) and 4 were postmenopausal (mean FSH 90.5 ± 11.0 iu/l). At every site measured BMD was greatest in those women classified as premenopausal and...
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